| Identification | Back Directory | [Name]
2-Piperidinone, 1-[(2E)-3-(4-hydroxy-3-methoxyphenyl)-1-oxo-2-propen-1-yl]-3-[(3,4,5-trimethoxyphenyl)methylene]-, (3E)- | [CAS]
2293951-01-4 | [Synonyms]
2-Piperidinone, 1-[(2E)-3-(4-hydroxy-3-methoxyphenyl)-1-oxo-2-propen-1-yl]-3-[(3,4,5-trimethoxyphenyl)methylene]-, (3E)- | [Molecular Formula]
C25H27NO7 | [MOL File]
2293951-01-4.mol | [Molecular Weight]
453.48 |
| Chemical Properties | Back Directory | [Boiling point ]
633.9±55.0 °C(Predicted) | [density ]
1.272±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
9.71±0.31(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
Anti-inflammatory agent 36 is an anti-inflammatory agent. Anti-inflammatory agent 36 inhibits LPS-induced macrophage activation[1]. | [in vivo]
Anti-inflammatory agent 36 (Compound 5a28) (10 mg/kg, i.p.) inhibits inflammation in acute lung injury mouse model[1].
| Animal Model: | Acute lung injury mouse model[1] | | Dosage: | 10 mg/kg | | Administration: | i.p. | | Result: | Reduced wet/dry weight ratio of the mice lungs.
Reduced biomarkers of lymphocytes and macrophages.
Suppresses TNF-α, IL-6, IL-1β, 7 VACM-1 and ICAM-1 level.
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| [References]
[1] Qian J, et al. Design and synthesis novel di-carbonyl analogs of curcumin (DACs) act as potent anti-inflammatory agents against LPS-induced acute lung injury (ALI). Eur J Med Chem. 2019 Apr 1;167:414-425. DOI:10.1016/j.ejmech.2019.02.042 |
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