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2294013-78-6

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2294013-78-6 Structure

2294013-78-6 Structure
IdentificationBack Directory
[Name]

anti-TB agent 1
[CAS]

2294013-78-6
[Synonyms]

anti-TB agent 1
antiTB agent 1,anti TB agent 1
Pyrazolo[1,5-a]pyridine-3-carboxamide, 5-methoxy-2-methyl-N-[[5-[4-(trifluoromethoxy)phenyl]-2-pyridinyl]methyl]-
[Molecular Formula]

C23H19F3N4O3
[MDL Number]

MFCD32062827
[MOL File]

2294013-78-6.mol
[Molecular Weight]

456.42
Chemical PropertiesBack Directory
[density ]

1.35±0.1 g/cm3(Predicted)
[pka]

10.76±0.46(Predicted)
Hazard InformationBack Directory
[Uses]

anti-TB agent 1 is a potent and orally active anti-tuberculosis agent, with MICs of < 2 nM against the Mtb strains H37Rv, rRMP and rINH[1].
[References]

[1] Hu X, et al. Identification of Pyrazolo[1,5-a]pyridine-3-carboxamide Diaryl Derivatives as Drug Resistant Antituberculosis Agents. ACS Med Chem Lett. 2019 Feb 21;10(3):295-299. DOI:10.1021/acsmedchemlett.8b00410
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