| Identification | Back Directory | [Name]
PHOSPHORIC ACI DI-T-BUTYL EXTER CHLOROMETHYL ESTER | [CAS]
229625-50-7 | [Synonyms]
Fostemsavir-SM
Foscarbidopa Impurity 20
Di-t-butyl chloromethyl phosphate
ditetrabutyl chloromethyl phosphate
Di-tert-butyl Chloromethyl Phosphate
Chloromethyl di-tert-butyl phosphate
Di-tert-butyl chloromethyl phosphate 95%
Di tertiary butyl chloromethyl phosphite
Phosphoric acid di-tert-butyl chloromethyl ester
PHOSPHORIC ACI DI-T-BUTYL EXTER CHLOROMETHYL ESTER
Phosphoric acid di-t-butyl ester chloromethyl ester
Phosphoric acid ditert-butyl ester chloromethyl ester
PHOSPHORIC ACI DI-Tert-BUTYL EXTER CHLOROMETHYL ESTER
Phosphoric acid, chloroMethyl bis(1,1-diMethylethyl) ester
Di-tert-butyl ChloromethylPhosphate (stabilized with K2CO3)
TIANFUCHEM-- PHOSPHORIC ACI DI-T-BUTYL EXTER CHLOROMETHYL ESTER
Di-tert-butyl (chloromethyl) phosphate (stabilized with potassium carbonate) | [Molecular Formula]
C9H20ClO4P | [MDL Number]
MFCD12165895 | [MOL File]
229625-50-7.mol | [Molecular Weight]
258.679 |
| Chemical Properties | Back Directory | [Boiling point ]
272.9±23.0 °C(Predicted) | [density ]
1.115±0.06 g/cm3(Predicted) | [storage temp. ]
?20°C | [solubility ]
Benzene (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
Colourless Oil with White | [Stability:]
Moisture Sensitive | [InChI]
InChI=1S/C9H20ClO4P/c1-8(2,3)13-15(11,12-7-10)14-9(4,5)6/h7H2,1-6H3 | [InChIKey]
LNJAJHJFSKUCIR-UHFFFAOYSA-N | [SMILES]
P(OC(C)(C)C)(OC(C)(C)C)(OCCl)=O | [CAS DataBase Reference]
229625-50-7 |
| Hazard Information | Back Directory | [Description]
Di-tert-butyl (chloromethyl) phosphate has become one of the most common reagents to prepare phosphon-oxymethyl pro-drugs, generally by direct alkylation of hydroxyl or amino groups. Its synthesis was first reported in 1999 via a reaction of di-tert-butyl tetramethylammonium phosphate with chloroiodomethane. This approach required the use of the corresponding tetramethylammonium phosphate and a vast excess (>11 equiv) of chloroiodomethane to minimize the formation of tetra-tert-butyl methylene bisphosphate[1].
| [Uses]
Used as an intermediate for laboratory research. | [Synthesis]
Di-tert-butyl (chloromethyl) phosphate, a key compound in the formation of many phosphon-oxymethyl pro-drugs, is prepared by reacting chloromethyl chlorosulfate (CMCS) with di-tert-butyl potassium phosphate (DTBPP) . | [References]
[1] Bin Zheng*. “Development of Efficient Processes for the Preparation of Di-tert-butyl Potassium Phosphate and Di-tert-butyl (Chloromethyl) Phosphate.” Organic Process Research & Development 18 5 (2014): 636–642. |
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