| Identification | Back Directory | [Name]
Pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one, 2-[5-methyl-4-[[4-(2,2,2-trifluoroethyl)-1-piperidinyl]carbonyl]-1H-pyrazol-1-yl]- | [CAS]
2296727-52-9 | [Synonyms]
Pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one, 2-[5-methyl-4-[[4-(2,2,2-trifluoroethyl)-1-piperidinyl]carbonyl]-1H-pyrazol-1-yl]- | [Molecular Formula]
C18H19F3N6O2 | [MOL File]
2296727-52-9.mol | [Molecular Weight]
408.38 |
| Hazard Information | Back Directory | [Description]
QM385 is a potent sepiapterin reductase (SPR) inhibitor with an IC50 of 1.49 nM, which blocks T-cell proliferation and autoimmunity at nanomolar potency and with good oral bioavailability[1].
IC50: 1.49 nM (Sepiapterin reductase)[1] QM385 effectively inhibits the proliferation of human CD4+ T cells at low doses[1]. | [References]
[1]. Cronin SJF, et al. The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature. 2018 Nov;563(7732):564-568. |
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