| Identification | Back Directory | [Name]
(16S,22R)-14α,17α-Epoxy-7α,13,14,20,22-pentahydroxy-1,15-dioxo-16,24-cyclo-13,14-secoergosta-2,5,25(27)-triene-18,26-dioic acid 18,20:26,22-dilactone | [CAS]
23027-91-0 | [Synonyms]
Physalin A
(16S,22R)-14α,17α-Epoxy-7α,13,14,20,22-pentahydroxy-1,15-dioxo-16,24-cyclo-13,14-secoergosta-2,5,25(27)-triene-18,26-dioic acid 18,20:26,22-dilactone
(16S,22R)-14α,17α-Epoxy-7α,13,14,20,22-pentahydroxy-1,15-dioxo-16,24-cyclo-13,14-secoergosta-2,5,25(27)-triene-18,26-dioic acid 18,20:26,22-dilactone | [Molecular Formula]
C28H30O10 | [MOL File]
23027-91-0.mol | [Molecular Weight]
526.532 |
| Chemical Properties | Back Directory | [Boiling point ]
838.3±65.0 °C(Predicted) | [density ]
1.55±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
9.82±0.70(Predicted) | [color ]
White to off-white | [InChIKey]
VELDODQHYQSJOF-RKWIMMEGSA-N |
| Hazard Information | Back Directory | [Uses]
Physalin A is a bioactive withanolide which induces apoptosis via p-53-Noxa-mediated ROS generation. | [in vivo]
Physalin A (40-80 mg/kg; Intraperitoneal injection; 10 days) has antitumor effect in H292 xenograft tumor model[3].
Physalin A (2 μL 20 μM; Injection of nucleus pulposus of the disc; Single dose) has a protective effect in a rat model of disc degeneration[4]. | Animal Model: | Male BALB/c mice[3] | | Dosage: | 40 and 80 mg/kg | | Administration: | Intraperitoneal injection (i.p.); 10 days | | Result: | Significantly reduced the mean tumor volume and tumor weight, had the least effect on the weight of mice.
Decreased Tyr705-p-STAT3 levels, and increased caspase-3 activation.
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| Animal Model: | Male Sprague-Dawley rats aged 6-8 weeks old (220±20 g) with intervertebral disc degeneration[4] | | Dosage: | 2 μL 20 μM | | Administration: | Injection of nucleus pulposus of the disc; Single dose | | Result: | Alleviated disc degradation.
Reduced inflammation and fibrosis.
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| Spectrum Detail | Back Directory | [Spectrum Detail]
(16S,22R)-14α,17α-Epoxy-7α,13,14,20,22-pentahydroxy-1,15-dioxo-16,24-cyclo-13,14-secoergosta-2,5,25(27)-triene-18,26-dioic acid 18,20:26,22-dilactone(23027-91-0)1HNMR
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
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