| Identification | Back Directory | [Name]
Top1 inhibitor 1 | [CAS]
2302772-05-8 | [Synonyms]
Top1 inhibitor 1
Top1 inhibitor 1,Top-1 inhibitor 1
4-Quinolinamine, N-[3-(1H-imidazol-1-yl)propyl]-6-(4-methoxyphenyl)-3-(1,3,4-oxadiazol-2-yl)- | [Molecular Formula]
C24H22N6O2 | [MDL Number]
MFCD32062831 | [MOL File]
2302772-05-8.mol | [Molecular Weight]
426.47 |
| Hazard Information | Back Directory | [Uses]
Top1 inhibitor 1 (compound 28) is a potent human topoisomerase I (Top1) inhibitor with an IC50 value of 29 nM[1]. | [IC 50]
Camptothecins | [References]
[1] Kundu B, et al. Discovery and Mechanistic Study of Tailor-Made Quinoline Derivatives as Topoisomerase 1 Poison with Potent Anticancer Activity. J Med Chem. 2019 Apr 11; 62(7):3428-3446. DOI:10.1021/acs.jmedchem.8b01938 |
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