| Identification | Back Directory | [Name]
Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]- | [CAS]
2304621-31-4 | [Synonyms]
LDC195943(IMT1)
Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]- | [Molecular Formula]
C21H21NO4 | [MOL File]
2304621-31-4.mol | [Molecular Weight]
351.4 |
| Chemical Properties | Back Directory | [Boiling point ]
549.7±50.0 °C(Predicted) | [density ]
1.210±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 50 mg/mL (142.29 mM; Need ultrasonic) | [form ]
Solid | [pka]
-0.84±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
IMT1 is a first-in-class specific and noncompetitive human mitochondrial RNA polymerase (POLRMT) inhibitor. IMT1 causes a conformational change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. IMT1 reduces deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in a marked depletion of cellular amino acid levels. IMT1 has the potential for mitochondrial transcription disorders related diseases[1]. | [References]
[1] Nina A Bonekamp, et al. Small-molecule inhibitors of human mitochondrial DNA transcription. Nature. 2020 Dec;588(7839):712-716. DOI:10.1038/s41586-020-03048-z |
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| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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