| Identification | Back Directory | [Name]
BRD7-IN-1 free base | [CAS]
2305379-66-0 | [Synonyms]
BRD7-IN-1 free base
2,7-Naphthyridin-1(2H)-one, 4-[3,5-dimethoxy-4-(1-piperazinylmethyl)phenyl]-2-methyl- | [Molecular Formula]
C22H26N4O3 | [MDL Number]
MFCD32062735 | [MOL File]
2305379-66-0.mol | [Molecular Weight]
394.47 |
| Hazard Information | Back Directory | [Uses]
BRD7-IN-1 free base, a modified derivative of BI7273 (BRD7/9 inhibitor), binds to a VHL ligand via a linker to form a PROTAC VZ185 (VZ185 against BRD7/9 with DC50s of 4.5 and 1.8 nM, respectively)[1]. | [References]
[1] Zoppi V, et al. Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7. J Med Chem. 2019 Jan 24;62(2):699-726. DOI:10.1021/acs.jmedchem.8b01413 |
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