| Identification | Back Directory | [Name]
Microtubule inhibitor 1 | [CAS]
2305668-80-6 | [Synonyms]
EW-7197 HCl
Microtubule inhibitor 1
2-Propen-1-one, 3-(3-hydroxy-4-methoxyphenyl)-2-methyl-1-(2-methyl-4-quinolinyl)-, (2E)- | [Molecular Formula]
C21H19NO3 | [MDL Number]
MFCD32067904 | [MOL File]
2305668-80-6.mol | [Molecular Weight]
333.38 |
| Chemical Properties | Back Directory | [Boiling point ]
558.1±50.0 °C(Predicted) | [density ]
1.224±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
9.40±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
Microtubule inhibitor 1 is an antitumor agent with microtubule polymerization inhibitory activity, with an IC50 value of 9-16 nM in cancer cells[1]. | [storage]
Store at -20°C | [References]
[1] Li W, et al. Discovery of Novel Quinoline-Chalcone Derivatives as Potent Antitumor Agents with Microtubule Polymerization Inhibitory Activity. J Med Chem. 2019 Jan 24;62(2):993-1013. DOI:10.1021/acs.jmedchem.8b01755 |
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