| Identification | Back Directory | [Name]
BMS-284640 | [CAS]
230640-88-7 | [Synonyms]
BMS-284640
XP87V064PV
CHEMBL51879
UNII-XP87V064PV
BMS284640,BMS 284640
Cyclopropanecarboxamide, N-(aminoiminomethyl)-3-(2,3-dihydro-4-benzofuranyl)-2,2-dimethyl-, (1R,3R)- | [Molecular Formula]
C15H19N3O2 | [MOL File]
230640-88-7.mol | [Molecular Weight]
273.33 |
| Hazard Information | Back Directory | [Uses]
BMS-284640 is a synthetic sodium hydrogen exchange isomer-1 (NHE-1) inhibitor. BMS-284640 has a more than 380-fold higher NHE-1 inhibitory activity (IC50: 9 nM) compared to cariporide (HY-19693) and is more selective for NHE-1 over NHE-2 (IC50: 1.8 μM) and NHE-5 (IC50: 3.36 μM). BMS-284640 and its analogs also exhibit enhanced oral bioavailability and prolonged plasma half-life in rats.[1]. | [References]
[1] Arylcyclopropanecarboxyl Guanidines as Novel, Potent, and Selective Inhibitors of the Sodium Hydrogen Exchanger Isoform-1 |
|
|