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2307277-93-4

2307277-93-4 Structure

2307277-93-4 Structure
IdentificationBack Directory
[Name]

Spiro[2.2]pentane-1-carbonitrile, 1-[1-[6-[(3R)-3-(1-hydroxy-1-methylethyl)-1-pyrrolidinyl]-4-pyrimidinyl]-1H-indazol-6-yl]-, (1S)-
[CAS]

2307277-93-4
[Synonyms]

LRRK2-IN-7
Spiro[2.2]pentane-1-carbonitrile, 1-[1-[6-[(3R)-3-(1-hydroxy-1-methylethyl)-1-pyrrolidinyl]-4-pyrimidinyl]-1H-indazol-6-yl]-, (1S)-
[Molecular Formula]

C24H26N6O
[MOL File]

2307277-93-4.mol
[Molecular Weight]

414.5
Chemical PropertiesBack Directory
[Boiling point ]

636.0±55.0 °C(Predicted)
[density ]

1.42±0.1 g/cm3(Predicted)
[form ]

Solid
[pka]

15.07±0.29(Predicted)
[color ]

Off-white to pink
Hazard InformationBack Directory
[Uses]

LRRK2-IN-7 is a potent, selective, and CNS-penetrant LRRK2 kinase?inhibitor with an IC50 of 0.9 nM. LRRK2-IN-7 shows >1000-fold selectivity over other kinases, ion channels, and CYP enzymes[1].
[in vivo]

In a 7 day rat dose limiting toxicity study, LRRK2-IN-7 (compound 25) is tolerated with no significant histopathology findings up to 100 mg/kg once a day (AUCtot = 330 μM·h)[1].
In an acute (2 h) rat PK/PD study, LRRK2-IN-7 (compound 25) demonstrates a dose-dependent decrease in LRRK2 pS935 in rat brain striatum with an EC50 = 0.18 nM[1].

[References]

[1] David A Candito, et al. Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1 H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease. J Med Chem. 2022 Dec 22;65(24):16801-16817. DOI:10.1021/acs.jmedchem.2c01605
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