| Identification | Back Directory | [Name]
Pip-alkyne-Ph-COOCH3 | [CAS]
2308496-47-9 | [Synonyms]
Pip-alkyne-Ph-COOCH3
Benzoic acid, 4-[2-(4-piperidinyl)ethynyl]-, methyl ester | [Molecular Formula]
C15H17NO2 | [MDL Number]
MFCD32633124 | [MOL File]
2308496-47-9.mol | [Molecular Weight]
243.3 |
| Hazard Information | Back Directory | [Uses]
Pip-alkyne-Ph-COOCH3 is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTAC ARD-266[1]. Pip-alkyne-Ph-COOCH3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
Alkyl-Chain | [References]
[1] Han X, et al. Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands. J Med Chem. 2019 Dec 26;62(24):11218-11231. DOI:10.1021/acs.jmedchem.9b01393 |
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