| Identification | Back Directory | [Name]
4(3H)-Pyrimidinone, 2-[1-[[1-(2-pyrimidinyl)-1H-imidazol-4-yl]methyl]-3-piperidinyl]-6-(2-thienyl)- | [CAS]
2309762-18-1 | [Synonyms]
4(3H)-Pyrimidinone, 2-[1-[[1-(2-pyrimidinyl)-1H-imidazol-4-yl]methyl]-3-piperidinyl]-6-(2-thienyl)- | [Molecular Formula]
C21H21N7OS | [MOL File]
2309762-18-1.mol | [Molecular Weight]
419.5 |
| Chemical Properties | Back Directory | [Boiling point ]
672.0±65.0 °C(Predicted) | [density ]
1.47±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
8.44±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Ribocil-C Racemate is the racemate of Ribocil-C. Ribocil-C is a highly selective inhibitor of bacterial riboflavin riboswitches. | [in vivo]
Higher dose Ribocil-C treatment groups (60 and 120 mg kg21 ribocil-C) demonstrate a dose-dependent reduction in bacterial burden of 1.87 and 3.29 log10[CFU per g spleen] reduction respectively versus shamtreated mice, without mortality or gross effects of toxicity observed[2]. | [References]
[1] Wang H, et al. Dual-Targeting Small-Molecule Inhibitors of the Staphylococcus aureus FMN Riboswitch DisruptRiboflavin Homeostasis in an Infectious Setting. Cell Chem Biol. 2017 May 18;24(5):576-588. DOI:10.1016/j.chembiol.2017.03.014
[2] Howe JA, et al. Selective small-molecule inhibition of an RNA structural element. Nature. 2015 Oct 29;526(7575):672-7. DOI:10.1038/nature15542 |
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