| Identification | Back Directory | [Name]
Propanamide, N-(2-furanylmethyl)-3-[[4-(methylpropylamino)-6-(trifluoromethyl)-2-pyrimidinyl]thio]- | [CAS]
2313525-20-9 | [Synonyms]
Propanamide, N-(2-furanylmethyl)-3-[[4-(methylpropylamino)-6-(trifluoromethyl)-2-pyrimidinyl]thio]- | [Molecular Formula]
C17H21F3N4O2S | [MOL File]
2313525-20-9.mol | [Molecular Weight]
402.44 |
| Chemical Properties | Back Directory | [Boiling point ]
567.1±50.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO|40.24|100|ethanol|20.12|50| | [form ]
Solid | [pka]
14.58±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
SET2 is a novel selective TRPV2 antagonist. | [Uses]
SET2 is a selective TRPV2 antagonist (IC50=0.46 μM). SET2 blocks the TRP channel and suppresses prostate cancer cells migration. SET2 reduces the lysophosphatidic acid (LPA, a TRPV2 activator)-induced cytoplasmic calcium increases[1]. | [IC 50]
TRPV2: 0.46 μM (IC50) | [storage]
Store at -20°C | [References]
[1] Chai H, et al. Structure-Based Discovery of a Subtype-Selective Inhibitor Targeting a Transient Receptor Potential Vanilloid Channel. J Med Chem. 2019 Feb 14;62(3):1373-1384. DOI:10.1021/acs.jmedchem.8b01496 |
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