| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 125 mg/mL (184.03 mM) | [form ]
Solid | [color ]
Light brown to brown | [Water Solubility ]
Water: 10 mg/mL (14.72 mM) |
| Hazard Information | Back Directory | [Uses]
IACS-9571 (ASIS-P040) hydrochloride is a potent and selective inhibitor of TRIM24 and BRPF1, with an IC50 of 8 nM for TRIM24, and Kds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively[1]. | [References]
[1] Palmer WS, et al. Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor. J Med Chem. 2016 Feb 25;59(4):1440-54. DOI:10.1021/acs.jmedchem.5b00405 |
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