| Identification | Back Directory | [Name]
Methanesulfonamide, N-[[1-[6-(trifluoromethyl)-4-quinazolinyl]-3-piperidinyl]methyl]- | [CAS]
2322245-42-9 | [Synonyms]
SRI-37330
Methanesulfonamide, N-[[1-[6-(trifluoromethyl)-4-quinazolinyl]-3-piperidinyl]methyl]- | [Molecular Formula]
C16H19F3N4O2S | [MOL File]
2322245-42-9.mol | [Molecular Weight]
388.41 |
| Chemical Properties | Back Directory | [Boiling point ]
524.2±60.0 °C(Predicted) | [density ]
1.371±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, stored under nitrogen | [solubility ]
DMSO : 100 mg/mL (257.46 mM; Need ultrasonic) | [form ]
Solid | [pka]
11.14±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
SRI-37330 is a novel inhibitor of TXNIP expression, decreasing glucagon secretion and action and blocking hepatic glucose output, reversing obesity- and STZ-induced diabetes and hepatic steatosis. | [Uses]
SRI-37330 is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. SRI-37330 inhibits glucagon secretion and function, reduces hepatic glucose production and reverses hepatic steatosis. SRI-37330 can be used for type 2 diabetes research[1]. | [in vivo]
SRI-37330 (100 mg/kg, p.o., in drinking water, 3 weeks) decreases glucagon secretion and action and blocks hepatic glucose output[1].
SRI-37330 (100 mg/kg, p.o., in drinking water, 3 weeks) is well tolerated in male C57BL/6J mice[1].
SRI-37330 (100 mg/kg, p.o., in drinking water, 3 weeks) reverses obesity- and STZ-induced diabetes and hepatic steatosis in mice[1].
| Animal Model: | C57BL/6J mice[1] | | Dosage: | 100 mg/kg | | Administration: | Oral administration (p.o.), in drinking water, 3 weeks. | | Result: | Lowered serum glucagon levels, inhibited hepatic glucose production and improved glucose homeostasis in mice. |
| [References]
[1] Thielen LA, et al. Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action. Cell Metab. 2020 Sep 1;32(3):353-365.e8. DOI:10.1016/j.cmet.2020.07.002 |
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| Company Name: |
xinguokeji
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| Tel: |
13120711461 |
| Website: |
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