| Identification | Back Directory | [Name]
Methyltetrazine-amido-PEG5-alkyne | [CAS]
2322322-23-4 | [Synonyms]
Methyltetrazine-amido-PEG5-alkyne
N-(4-(6-Methyl-1,2,4,5-tetrazin-3-yl)benzyl)-4,7,10,13,16-pentaoxanonadec-18-ynamide | [Molecular Formula]
C24H33N5O6 | [MDL Number]
MFCD31811434 | [MOL File]
2322322-23-4.mol | [Molecular Weight]
487.55 |
| Chemical Properties | Back Directory | [density ]
1.181±0.06 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Solid | [pka]
14.29±0.46(Predicted) | [color ]
Purple to purplish red |
| Hazard Information | Back Directory | [Description]
Methyltetrazine-amido-PEG5-alkyne is a heterobifunctional crosslinker. This reagent enables simple and efficient incorporation of a tetrazine moiety onto TCO-attached antibodies, peptide or other biomolecule under mild condition. The alkynes is reactive with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry. PEG5 space increase the compound's aqueous solubility. | [Uses]
Methyltetrazine-amido-PEG5-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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