| Identification | Back Directory | [Name]
2,5-Dibromopyrazine | [CAS]
23229-26-7 | [Synonyms]
5-Dibromopyrazine
2,5-DIBROMOPYRAZINE
2,5-bisbromopyrazine
PYRAZINE,2,5-DIBROMO
2,5-Dibromopyrazine>
2,5-Dibromopyrazine 95% (GC)
2,5-Dibromopyrazine ISO 9001：2015 REACH
3,6-Dibromopyrazine, 2,5-Dibromo-1,4-diazine | [EINECS(EC#)]
805-812-6 | [Molecular Formula]
C4H2Br2N2 | [MDL Number]
MFCD08061601 | [MOL File]
23229-26-7.mol | [Molecular Weight]
237.88 |
| Chemical Properties | Back Directory | [Melting point ]
45.0 to 49.0 °C | [Boiling point ]
234.0±35.0 °C(Predicted) | [density ]
2.197 | [Fp ]
95℃ | [storage temp. ]
0-10°C | [form ]
powder to crystal | [pka]
-4.28±0.10(Predicted) | [color ]
White to Orange to Green | [InChI]
InChI=1S/C4H2Br2N2/c5-3-1-7-4(6)2-8-3/h1-2H | [InChIKey]
KIYKHEOWZLJZSB-UHFFFAOYSA-N | [SMILES]
C1(Br)=NC=C(Br)N=C1 | [CAS DataBase Reference]
23229-26-7 |
| Questions And Answer | Back Directory | [Application]
2,5-Dibromopyrazine is a common organic synthon that can serve as a molecular skeleton in the synthesis of bioactive molecules. |
| Hazard Information | Back Directory | [Synthesis]
5-bromopyrazin-2-amine (3 g, 17.241 mmol) and bromine (8.2 g, 51.729 mmol) were added to aq. HBr solution at -15° C. Aq. solution of sodium nitrite (2.97 g, 43.0103 mmol) was then added to the mixture over a period of 1 h at -10° C. keeping the internal temperature below 5° C. during addition and stirred for 1 h at 0° C. Progress of reaction was monitored by TLC. After reaction completion reaction mass neutralised with 40percent NaOH solution and extracted with diethyl ether. The organic layer was dried over sodium sulphate and concentrated under reduced pressure (below 30° C.) to yield 2,5-Dibromopyrazine (1 g, 24.4percent) as brown oil. | [References]
[1] Patent: US2017/291910, 2017, A1. Location in patent: Paragraph 0592-0594
[2] Journal of the American Chemical Society, 1949, vol. 71, p. 2798
[3] Chemistry - A European Journal, 2010, vol. 16, # 19, p. 5645 - 5660
[4] Patent: WO2004/56369, 2004, A1. Location in patent: Page/Page column 24-25 |
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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https://www.jkchemical.com |
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Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
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Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956 |
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https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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