| Identification | Back Directory | [Name]
1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrrolidinyl ester | [CAS]
2326428-25-3 | [Synonyms]
anticancer,Cyclin dependent kinase,CDK,MCF7,SNU-16,Cyclin-dependent kinase,LY 3405105,LY3405105,HCC1806,inhibit,Inhibitor,LY-3405105,HCT116
(3S)-1-[(E)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl] 4-[(3-isopropyl-5-methylpyrazolo[1,5-a]pyrimidin-7-yl)amino]piperidine-1-carboxylate
1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrrolidinyl ester | [Molecular Formula]
C26H39N7O3 | [MDL Number]
MFCD34593625 | [MOL File]
2326428-25-3.mol | [Molecular Weight]
497.63 |
| Chemical Properties | Back Directory | [density ]
1.27±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 99 mg/mL (198.94 mM);Ethanol: 99 mg/mL (198.94 mM) | [form ]
Solid | [pka]
8.26±0.28(Predicted) | [color ]
White to off-white | [Water Solubility ]
Water: Insoluble |
| Hazard Information | Back Directory | [Uses]
CDK7-IN-4 (compound I) is a potent CDK7 (Cyclin-dependent kinase 7) inhibitor. CDK7-IN-4 shows anticancer activity. CDK7-IN-4 inhibits the in vitro growth of cancer cell lines from a variety of histologies including colon , breast , lung , ovary and stomach , in a dose dependent manner[1]. | [IC 50]
CDK7 | [storage]
Store at -20°C | [References]
[1] David Andrew Coates,et al. Compounds useful for inhibiting cdk7. US20190144456A1. |
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