ChemicalBook--->CAS DataBase List--->2327925-35-7

2327925-35-7

2327925-35-7 Structure

2327925-35-7 Structure
IdentificationBack Directory
[Name]

MT-4
[CAS]

2327925-35-7
[Synonyms]

MT-4
[Molecular Formula]

C21H23N5O
[MDL Number]

MFCD32068347
[MOL File]

2327925-35-7.mol
[Molecular Weight]

361.44
Chemical PropertiesBack Directory
[density ]

1.246±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Solid
[pka]

14.54±0.70(Predicted)
[color ]

Off-white to light yellow
[Cosmetics Ingredients Functions]

SKIN PROTECTING
ANTIOXIDANT
SKIN CONDITIONING
Hazard InformationBack Directory
[Uses]

MT-4 is a derivative of a tissue transglutaminase (TG2) inhibitor. MT-4 targets the complex of TG2 and fibronectin (FN) (TG2/FN) and inhibits the adhesion of tumor cells to the matrix. MT-4 inhibits the adhesion of ovarian cancer (OC) cells to the peritoneum and increases the sensitivity of OC cells to paclitaxel.
[References]

[1] Sima LE, et al. Small Molecules Target the Interaction between Tissue Transglutaminase and Fibronectin. Mol Cancer Ther. 2019 Jun;18(6):1057-1068. DOI:10.1158/1535-7163.MCT-18-1148
Spectrum DetailBack Directory
[Spectrum Detail]

MT-4(2327925-35-7)1HNMR
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