| Identification | Back Directory | [Name]
1,2-Propanediol, 3-[4-[1-ethyl-1-[4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl]propyl]-2-methylphenoxy]- | [CAS]
233268-81-0 | [Synonyms]
LG190178
LG-190178
LG 190178
1,2-Propanediol, 3-[4-[1-ethyl-1-[4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl]propyl]-2-methylphenoxy]- | [Molecular Formula]
C28H42O5 | [MOL File]
233268-81-0.mol | [Molecular Weight]
458.63 |
| Hazard Information | Back Directory | [Description]
LG190178 is a vitamin D receptor (VDR) ligand that is a therapeutic agent for the treatment of psoriasis, osteoporosis, and secondary hyperparathyroidism. | [Uses]
LG190178 is a non-steroidal vitamin D receptor (VDR) ligand that can induce the formation of heterodimer complexes between VDR and retinoid X receptor (RXR), stabilizing the agonistic conformation of the VDR ligand-binding domain and promoting its interaction with co-activators. LG190178 has functions in regulating calcium homeostasis, bone mineralization, as well as cell proliferation, differentiation, and apoptosis, making it useful for research in psoriasis, osteoporosis, and cancer[1]. | [in vitro]
LG190178 is a novel non-secosteroidal ligand for VDR._x000D_
_x000D_
Reference: Bioorg Med Chem Lett. 2008 Jan 1;18(1):120-3. https://pubmed.ncbi.nlm.nih.gov/18054230/ | [target]
LG190178 is a vitamin D receptor (VDR) ligand that is a therapeutic agent for the treatment of psoriasis, osteoporosis, and secondary hyperparathyroidism. | [References]
[1] Perakyla, et al. Gene regulatory potential of nonsteroidal vitamin D receptor ligands. Molecular endocrinology 19.8 (2005): 2060-2073. DOI:10.1210/me.2004-0417 |
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