| Identification | Back Directory | [Name]
4-chloromorpholine | [CAS]
23328-69-0 | [Synonyms]
Einecs 245-588-1
4-chloromorpholine
N-Chloromorpholine
Morpholine, 4-chloro- | [EINECS(EC#)]
245-588-1 | [Molecular Formula]
C4H8ClNO | [MDL Number]
MFCD03095600 | [MOL File]
23328-69-0.mol | [Molecular Weight]
121.57 |
| Hazard Information | Back Directory | [Uses]
4-chloromorpholine is a useful reagent for selective and efficient chlorination of activated aromatics.
| [Synthesis Reference(s)]
1. Smith, J. R. L.; McKeer, L. C.; Taylor, J. M. OSC 1993, 8, 167.
2. Smith, J. R. L.; McKeer, L. C.; Taylor, J. M. JCS(P2) 1987, 1533.
| [Synthesis]
4-chloromorpholine is synthesized by Morpholine and aqueous Sodium Hypochlorite at <10 °C, followed by ether extraction, concentration below 30 °C, and vacuum distillation.1,2
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