| Chemical Properties | Back Directory | [density ]
1.456±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 300 mg/mL (326.85 mM; Need ultrasonic) | [form ]
Solid | [pka]
10.69±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
BI-3663 is a highly selective PTK2/FAK PROTAC (DC50=30 nM), with Cereblon ligands to hijack E3 ligases for PTK2 degradation. BI-3663 inhibits PTK2 with an IC50 of 18 nM. BI-3663 is a PROTAC that composes of BI-4464 (HY-124625) linked to Pomalidomide (HY-10984) with a linker[1]. Anti-cancer activity[1]. | [IC 50]
PTK2/FAK: 18 nM (IC50); Cereblon | [References]
[1] Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62(5):2508-2520. DOI:10.1021/acs.jmedchem.8b01826 |
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MedChemExpress
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021-58955995 |
| Website: |
www.medchemexpress.com |
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