| Identification | Back Directory | [Name]
3-BUTYNOIC ACID | [CAS]
2345-51-9 | [Synonyms]
CHequivCCH2COOH
3-Bytynoic Acid
But-3-ynoic acid
Ethynylacetic acid
3-Butynoic acid 95%
2-Ethynylacetic acid
3-butynoic acid(SALTDATA: FREE) | [Molecular Formula]
C4H4O2 | [MDL Number]
MFCD02258494 | [MOL File]
2345-51-9.mol | [Molecular Weight]
84.08 |
| Chemical Properties | Back Directory | [Melting point ]
188-195℃ | [Boiling point ]
195℃ | [density ]
1.152 | [Fp ]
83℃ | [storage temp. ]
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | [solubility ]
Chloroform, Methanol (Slightly) | [form ]
powder to crystal | [pka]
3.62±0.10(Predicted) | [color ]
White to Almost white | [λmax]
228nm(CH2Cl2)(lit.) | [InChI]
InChI=1S/C4H4O2/c1-2-3-4(5)6/h1H,3H2,(H,5,6) | [InChIKey]
KKAHGSQLSTUDAV-UHFFFAOYSA-N | [SMILES]
C(O)(=O)CC#C |
| Hazard Information | Back Directory | [Uses]
Some of the applications of 3-butynoic acid are:
- Synthesis of functionalized γ-butyrolactones and tetrahydrofurans via Conia-ene cyclizations.
- Synthesis of allenoates for [2+2] cycloadditions with alkenes.
- Phosphine-catalyzed synthesis of highly functionalized coumarins.
- Synthesis of various useful organotin reagents via radical hydrostannation of 3-butynoic acid.
| [Definition]
ChEBI: A monocarboxylic acid consisting of acetylene carrying a carboxymethyl group. | [Synthesis]
Under nitrogen protection, 120 g of 3-bromopropyne was slowly added dropwise to a 1000 ml three-necked flask containing 24 g of magnesium shavings and 300 ml of tetrahydrofuran, and the reaction was carried out for 60 min at room temperature. Subsequently, an excess of carbon dioxide was passed into the reaction system and heated to 60 °C. Upon completion of the reaction, the mixture was poured into cooled 200 ml of saturated aqueous ammonium chloride solution and extracted to separate the organic layer. The organic layer was dried with anhydrous sodium sulfate, filtered and concentrated. The crude product 3-butynoic acid was recrystallized with 50 ml of methyl tert-butyl ether and filtered to obtain crystals. After drying, 70 g of 3-butynoic acid with 98.3% purity was obtained. | [IC 50]
Human Endogenous Metabolite | [References]
[1] Patent: CN105481683, 2016, A. Location in patent: Paragraph 0021; 0022
[2] Angewandte Chemie - International Edition, 2013, vol. 52, # 35, p. 9266 - 9270
[3] Angew. Chem., 2013, vol. 125, # 35, p. 9436 - 9440
[4] Chemistry - A European Journal, 2015, vol. 21, # 14, p. 5561 - 5583
[5] Journal of the American Chemical Society, 2015, vol. 137, # 10, p. 3482 - 3485 |
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