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2349393-04-8

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2349393-04-8 Structure

2349393-04-8 Structure
IdentificationBack Directory
[Name]

KRAS G12C inhibitor 17
[CAS]

2349393-04-8
[Synonyms]

KRAS G12C inhibitor 17
KRAS G-12C inhibitor 17,KRAS G12C inhibitor 17
2-Propen-1-one, 1-[(2R,4aR)-11-chloro-9-fluoro-10-(2-fluoro-6-hydroxyphenyl)-1,2,4a,5-tetrahydro-2-methylpyrazino[1',2':4,5][1,4]oxazino[2,3-c]quinolin-3(4H)-yl]-
[Molecular Formula]

C24H20ClF2N3O3
[MDL Number]

MFCD32201078
[MOL File]

2349393-04-8.mol
[Molecular Weight]

471.88
Chemical PropertiesBack Directory
[Boiling point ]

643.4±55.0 °C(Predicted)
[density ]

1.50±0.1 g/cm3(Predicted)
[pka]

6.72±0.35(Predicted)
Hazard InformationBack Directory
[Uses]

KRAS G12C inhibitor 17 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 82, has an IC50 of 5 nM[1].
[IC 50]

KRas G12C: 5 nM (IC50)
[References]

[1] Jason Grant Kettle, et al. Tetracyclic compounds as inhibitors of g12c mutant ras protein, for use as anti-cancer agents. WO2019110751A1.
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