| Identification | Back Directory | [Name]
1H-Pyrazino[1',2':4,5]pyrazino[2,3-c]quinolin-5(6H)-one, 11-chloro-9-fluoro-10-(2-fluoro-6-hydroxyphenyl)-2,3,4,4a-tetrahydro-6-methyl-3-(1-oxo-2-propen-1-yl)-, (4aR)- | [CAS]
2349393-95-7 | [Synonyms]
1H-Pyrazino[1',2':4,5]pyrazino[2,3-c]quinolin-5(6H)-one, 11-chloro-9-fluoro-10-(2-fluoro-6-hydroxyphenyl)-2,3,4,4a-tetrahydro-6-methyl-3-(1-oxo-2-propen-1-yl)-, (4aR)- | [Molecular Formula]
C24H19ClF2N4O3 | [MOL File]
2349393-95-7.mol | [Molecular Weight]
484.88 |
| Chemical Properties | Back Directory | [Boiling point ]
733.1±60.0 °C(Predicted) | [density ]
1.56±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C, protect from light, stored under nitrogen | [solubility ]
DMSO : 100 mg/mL (206.24 mM; Need ultrasonic) | [form ]
Solid | [pka]
6.72±0.35(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
KRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 17, has an IC50 of 18 nM[1]. | [Biological Activity]
KRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 17, has an IC50 of 18 nM[1]. | [IC 50]
KRas G12C: 18 nM (IC50) | [storage]
Store at -20°C, protect from light, stored under nitrogen | [References]
[1]. Jason Grant Kettle, et al. Tetracyclic compounds as inhibitors of g12c mutant ras protein, for use as anti-cancer agents. WO2019110751A1. |
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