| Identification | Back Directory | [Name]
Methyltetrazine-PEG8-PFP ester | [CAS]
2353409-49-9 | [Synonyms]
Methyltetrazine-PEG8-PFP ester | [Molecular Formula]
C34H43F5N4O11 | [MDL Number]
MFCD31811432 | [MOL File]
2353409-49-9.mol | [Molecular Weight]
778.72 |
| Chemical Properties | Back Directory | [Boiling point ]
779.2±70.0 °C(Predicted) | [density ]
1.292±0.06 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Oil | [pka]
1.67±0.10(Predicted) | [color ]
Purple to purplish red |
| Hazard Information | Back Directory | [Description]
Methyltetrazine-PEG8-PFP ester is an PFP containing click chemistry reagent consisting of a methyltetrazine group. NHS ester is reactivewith primary amines such as the side chain of lysine residue or aminosilane-coated surfaces at neutral or slightly basic pH to form covalent bonds. Thus, this reagent can be used for modification of amine-containing molecules in organic media and the low mass weight will add minimal spacer to modified molecules. Methyltetrazine is reaactive with TCO via click chemistry. | [Uses]
Methyltetrazine-PEG8-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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