| Identification | Back Directory | [Name]
Biotin-PEG4-Dde-TAMRA-PEG3-Azide | [CAS]
2353409-56-8 | [Synonyms]
Dde TAMRA Biotin Azide
Biotin-PEG4-Dde-TAMRA-PEG3-Azide | [Molecular Formula]
C69H97N12O17S+ | [MDL Number]
MFCD34470009 | [MOL File]
2353409-56-8.mol | [Molecular Weight]
1398.66 |
| Hazard Information | Back Directory | [Description]
Dde TAMRA Biotin Azide is a trifunctional, cleavable probe that allows for efficient recovery of avidin-bound protein complexes in affinity-based assays. This reagent contains a fluorescent dye (TAMRA) and biotin moiety linked to azide group through a spacer arm containing a hydrazine-cleavable Dde moiety. Under mild conditions (2% aqueous hydrazine), the Dde liner is cleaved, releasing the biotin tag and any avidin conjugate bound to it. | [Uses]
Biotin-PEG4-Dde-TAMRA-PEG3-Azide is a dye derivative of TAMRA (HY-135640) modified with a cleavable biotin group. Biotin-PEG4-Dde-TAMRA-PEG3-Azide contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
Cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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MedChemExpress
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www.medchemexpress.com |
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