| Identification | Back Directory | [Name]
INDEX NAME NOT YET ASSIGNED | [CAS]
2353536-67-9 | [Synonyms]
β-catenin-IN-4
5-Chloroindole-2-carboxylic acid-2Nal-Asp-Glu-4-(Trifluoromethoxy)aniline | [Molecular Formula]
C38H33ClF3N5O9 | [MOL File]
2353536-67-9.mol | [Molecular Weight]
796.15 |
| Chemical Properties | Back Directory | [Boiling point ]
1177.2±65.0 °C(Predicted) | [density ]
1.490±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
4.18±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
β-catenin-IN-4 (Compound 39) is a β-catenin inhibitor with a Ki of 0.64 μM. β-catenin-IN-4 reduces the protein expression levels of cyclin D1 and c-Myc[1]. | [References]
[1] McCoy MA, et al. Biophysical Survey of Small-Molecule β-Catenin Inhibitors: A Cautionary Tale. J Med Chem. 2022 May 26;65(10):7246-7261. DOI:10.1021/acs.jmedchem.2c00228 |
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