| Identification | Back Directory | [Name]
Gly-PEG3-endo-BCN | [CAS]
2354291-37-3 | [Synonyms]
Gly-PEG3-endo-BCN
Gly-PEG3-endo-BCN, TFA salt | [Molecular Formula]
C23H39N3O6 | [MDL Number]
MFCD31811481 | [MOL File]
2354291-37-3.mol | [Molecular Weight]
453.57 |
| Chemical Properties | Back Directory | [Boiling point ]
656.9±55.0 °C(Predicted) | [density ]
1.16±0.1 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [pka]
12.48±0.46(Predicted) |
| Hazard Information | Back Directory | [Description]
Gly-PEG3-endo-BCN is a click chemistry reagent. The hydrophilic PEG spacer increases solubility in aqueous media. | [Uses]
Gly-PEG3-endo-BCN is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Gly-PEG3-endo-BCN is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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