| Identification | Back Directory | [Name]
Methanesulfonamide, N-[2-[(4S)-4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-11-yl]ethyl]-N-(1-methylethyl)- | [CAS]
2356229-14-4 | [Synonyms]
Methanesulfonamide, N-[2-[(4S)-4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-11-yl]ethyl]-N-(1-methylethyl)- | [Molecular Formula]
C26H29N3O6S | [MOL File]
2356229-14-4.mol | [Molecular Weight]
511.59 |
| Chemical Properties | Back Directory | [Boiling point ]
848.0±75.0 °C(Predicted) | [density ]
1.45±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C, protect from light | [form ]
Solid | [pka]
11.24±0.20(Predicted) | [color ]
Off-white to yellow | [InChIKey]
PGWIUEMZGPWFBB-SANMLTNESA-N | [SMILES]
CS(N(CCC1C2C(N=C3C4N(C(=O)C5COC(=O)[C@@](CC)(O)C=5C=4)CC3=1)=CC=CC=2)C(C)C)(=O)=O |
| Hazard Information | Back Directory | [Uses]
T01-1 is an anticancer agent (camptothecin derivative) with good anti-proliferative activity[1]. | [in vivo]
T01-1 (1 mg/kg; i.v.; single) shows T1/2 values of 2.78 and 1.97 h in female and male rats, respectively[1]. | Animal Model: | Sprague Dawley rat (half male and half female)[1]. | | Dosage: | 1 mg/kg | | Administration: | Intravenous injection; single | | Result: | 1.19Pharmacokinetic Parameters of T01-1 in Sprague Dawley rat [1].
| IV (1 mg/kg) | | Female | Male | | AUCLast (ng/mL?h) | 437 | 214 | | Cmax (ng/mL) | 838 | 625 | | MRTINF (h) | 2.81 | 0.44 | | T1/2 (h) | 2.78 | 1.97 | | Tmax (h) | 0.08 | 0.08 |
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| [storage]
Store at -20°C, protect from light | [References]
[1] Li Deliang, et al. Camptothecin derivative and water-soluble prodrug, pharmaceutical composition preparation method, and application. Patent WO2020156189A1. |
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