| Identification | Back Directory | [Name]
1H-Isoindole-1,3(2H)-dione, 2-[(3S)-2,6-dioxo-3-piperidinyl]-4-hydroxy- | [CAS]
2357105-36-1 | [Synonyms]
(S)-2-(2,6-Dioxopiperidin-3-yl)-4-hydroxyisoindoline-1,3-dione
1H-Isoindole-1,3(2H)-dione, 2-[(3S)-2,6-dioxo-3-piperidinyl]-4-hydroxy- | [Molecular Formula]
C13H10N2O5 | [MDL Number]
MFCD34601844 | [MOL File]
2357105-36-1.mol | [Molecular Weight]
274.23 |
| Chemical Properties | Back Directory | [Boiling point ]
568.3±45.0 °C(Predicted) | [density ]
1.611±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
6.82±0.20(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
(S)-Thalidomide-4-OH is the S-isomer of Thalidomide-4-OH (HY-103596). Thalidomide-4-OH (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) can be connected to the ligand for protein by a linker to form PROTACs[1]. | [References]
[1] Marks MG, et al. Effects of putative hydroxylated thalidomide metabolites on blood vessel density in the chorioallantoic membrane (CAM) assay and on tumor and endothelial cell proliferation. Biol Pharm Bull. 2002 May;25(5):597-604. DOI:10.1248/bpb.25.597 |
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