| Identification | Back Directory | [Name]
4-((17-amino-3,6,9,12,15-pentaoxaheptadecyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride | [CAS]
2357117-23-6 | [Synonyms]
Pomalidomide-NH-PEG5-amine hydrochlorid
Thalidomide-NH-PEG5-C2-NH2 hydrochloride
Pomalidomide-NH-PEG5-amine hydrochloride
4-((17-amino-3,6,9,12,15-pentaoxaheptadecyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride | [MDL Number]
MFCD32903279 | [MOL File]
2357117-23-6.mol | [Molecular Weight]
573.04 |
| Hazard Information | Back Directory | [Uses]
Pomalidomide-PEG5-C2-NH2 hydrochloride is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein.Pomalidomide-PEG5-C2-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC[1]. | [References]
[1] IVÁN CHENG-SÁNCHEZ, CRISTINA NEVADO* Discovery and Characterization of Active CBP/EP300 Degraders Targeting the HAT Domain[J]. ACS Medicinal Chemistry Letters, 2024, 15 3: 355-361. DOI: 10.1021/acsmedchemlett.3c00490
[2] SHULEI ZHU . Design, synthesis, and biological evaluation of Wee1 kinase degraders[J]. European Journal of Medicinal Chemistry, 2022, 243: Article 114786. DOI: 10.1016/j.ejmech.2022.114786 |
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