| Hazard Information | Back Directory | [Uses]
Bapotulimab (BAY-1905254) is a fully human IgG2 antibody targeting immunoglobulin-like domain containing receptor 2 (ILDR2). Bapotulimab has antitumor and immunosuppressive effects[1]. | [in vivo]
Bapotulimab (BAY-1905254; 10 mg/kg; i.p.; on days 1 and 4) shows significantly increased antigen-specific T-cell proliferation and cytotoxicity[1]. | Animal Model: | 8- to 12-week-old CD45.1-expressing C57BL/6 wild-type mice injected with OT-I transgenic T cells[1] | | Dosage: | 10 mg/kg | | Administration: |
i.p.; on days 1 and 4
| | Result: | Showed significantly increased antigen-specific T-cell proliferation and cytotoxicity. |
| [References]
[1] Julia Huetter, et al. Characterization of BAY 1905254, an Immune Checkpoint Inhibitor Targeting the Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2). Cancer Immunol Res. 2020 Jul;8(7):895-911. DOI:10.1158/2326-6066.CIR-19-0321 |
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| Company Name: |
Biolab Reagents
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| Tel: |
18108604356 18108604356 |
| Website: |
www.biolabreagent.com/ |
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