| Identification | Back Directory | [Name]
2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- | [CAS]
2359705-88-5 | [Synonyms]
Lenalidomide-F
2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- | [Molecular Formula]
C13H11FN2O3 | [MOL File]
2359705-88-5.mol | [Molecular Weight]
262.24 |
| Chemical Properties | Back Directory | [Boiling point ]
542.9±50.0 °C(Predicted) | [density ]
1.461±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
10.63±0.40(Predicted) | [color ]
Off-white to gray |
| Hazard Information | Back Directory | [Uses]
Lenalidomide-F is a E3 ligase ligand for LWY713. LWY713 is a PROTAC-class FLT3 degrader (DC50 = 0.64 nM), which selectively induces FLT3 degradation via cereblon and proteasome-dependent pathways[1]. | [IC 50]
Cereblon | [References]
[1] Liu W et al. Discovery of LWY713 as a potent and selective FLT3 PROTAC degrader with in vivo activity against acute myeloid leukemia. Eur J Med Chem. 2023 Nov 19;264:115974. DOI:10.1016/j.ejmech.2023.115974 |
|
|