| Identification | Back Directory | [Name]
HEXAETHYLENE GLYCOL MONOMETHYL ETHER | [CAS]
23601-40-3 | [Synonyms]
MPEG-6
MPEG6-OH
m-PEG6-alcohol
Methyl-PEG6-alcohol
3,6,9,12,15,18-Hexaoxanonadecan-1-ol
HexaethyleneGlycolMonomethylEther>
HEXAETHYLENE GLYCOL MONOMETHYL ETHER
2,5,8,11,14,17-hexaoxanonadecan-19-ol
3,6,9,12,15,18-Hexaoxanonadecane-1-ol
HEXAETHYLENE GLYCOL MONOMETHYL ETHER ISO 9001：2015 REACH
2-[2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol | [EINECS(EC#)]
245-775-8 | [Molecular Formula]
C13H28O7 | [MDL Number]
MFCD00045996 | [MOL File]
23601-40-3.mol | [Molecular Weight]
296.36 |
| Chemical Properties | Back Directory | [Boiling point ]
167 °C / 1mmHg | [density ]
1,08 g/cm3 | [refractive index ]
1.4510-1.4550 | [storage temp. ]
-20°C | [form ]
clear liquid | [pka]
14.36±0.10(Predicted) | [color ]
Colorless to Light yellow to Light orange | [InChI]
InChI=1S/C13H28O7/c1-15-4-5-17-8-9-19-12-13-20-11-10-18-7-6-16-3-2-14/h14H,2-13H2,1H3 | [InChIKey]
FHHGCKHKTAJLOM-UHFFFAOYSA-N | [SMILES]
C(O)COCCOCCOCCOCCOCCOC | [CAS DataBase Reference]
23601-40-3 | [EPA Substance Registry System]
2,5,8,11,14,17-Hexaoxanonadecan- 19-ol(23601-40-3) |
| Hazard Information | Back Directory | [Description]
m-PEG6-alcohol is a PEG linker containing a hydroxyl group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The hydrophilic PEG spacer increases solubility in aqueous media. | [Uses]
Applications may include: bioconjugation, drug delivery, PEG hydrogel, crosslinker, and surface functionalization | [Definition]
ChEBI: Hexaethylene glycol monomethyl ether is a hydroxypolyether. It is functionally related to a hexaethylene glycol. | [reaction suitability]
reagent type: cross-linking reagent | [Synthesis]
Under stirring conditions, 2-(2-(2-methoxyethoxy)ethoxy)ethyl 4-methylbenzenesulfonate (1.0 g, 3.14 mmol) was slowly added to triethylene glycol (2.10 mL, 15.7 mmol). Subsequently, potassium hydroxide (510 mg, 9.42 mmol) was ground into a fine powder and added to the reaction system. The reaction mixture was refluxed at 100 °C for 12 hours. After completion of the reaction, the reaction mixture was diluted with deionized water (50 mL) and extracted with dichloromethane. The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to afford 2,5,8,11,14,17-hexaoxanonadecan-19-ol as a yellow oil in 69% yield. | [IC 50]
PEGs | [References]
[1] Journal of Organic Chemistry, 2006, vol. 71, # 20, p. 7499 - 7508
[2] Organic Letters, 2004, vol. 6, # 4, p. 469 - 472
[3] Patent: WO2015/143185, 2015, A1. Location in patent: Paragraph 00819
[4] Patent: WO2016/40891, 2016, A2. Location in patent: Paragraph 00316
[5] Bulletin of the Korean Chemical Society, 2011, vol. 32, # 7, p. 2193 - 2198 |
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