| Identification | Back Directory | [Name]
Acetamide, 2-chloro-N-[4-(4-methoxyphenoxy)phenyl]-N-(phenylmethyl)- | [CAS]
2361138-33-0 | [Synonyms]
CCW16
Acetamide, 2-chloro-N-[4-(4-methoxyphenoxy)phenyl]-N-(phenylmethyl)-
N-Benzyl-2-chloro-N-(4-(4-methoxyphenoxy)phenyl)acetamide, E3 ubiquitin ligase ligand, Ligand for PROTAC? research, RNF4-targeting ligand | [Molecular Formula]
C22H20ClNO3 | [MDL Number]
MFCD34166235 | [MOL File]
2361138-33-0.mol | [Molecular Weight]
381.85 |
| Chemical Properties | Back Directory | [Boiling point ]
533.2±50.0 °C(Predicted) | [density ]
1.240±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [form ]
Solid | [pka]
0.86±0.50(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
CCW16 is a cofactor for the synthesis of protein degraders, such as PROTACs CCW 28-3 (HY-156774). | [reaction suitability]
reagent type: ligand | [IC 50]
RNF4 | [References]
[1] Ward CC, et, al. Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. DOI:10.1021/acschembio.8b01083 |
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Merck KGaA
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