| Chemical Properties | Back Directory | [Boiling point ]
813.3±65.0 °C(Predicted) | [density ]
0.965±0.06 g/cm3(Predicted) | [solubility ]
Ethanol: 25 mg/ml | [form ]
Liquid | [pka]
9.34±0.28(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
TCL053 is an ionizable amino lipid. It has been used in the generation of lipid nanoparticles. | [Uses]
TCL053 is an ionizable lipid carrier and used to introduce active components, in particular nucleic acids, into cells with excellent efriciency. TCL053, together with DPPC (Dipalmitoylphosphatidylcholine), PEG-DMG (Polyethylene glycoldimyristoyl glycerol), and cholesterol, forms lipid nanoparticle (LNP) which is able to deliver Cas9 mRNA and sgRNA into skeletal muscle[1][2]. | [in vivo]
TCL053-based LNP encapsulating Cas9 mRNA (TCL053-LNP-CRISPR) (20 μg total RNA; i.m.) exhibits high genome editing and exon skipping efficacy, and is higher than other in vivo mRNA delivery reagent (in vivo-jetRNA)[1].
TCL053-based LNP, via limb perfusion method, can target multiple muscle groups, with repeated administration and low immunogenicity features[1].
TCL053-based LNP acts as a delivery vehicle of CRISPR-Cas9 and can be used for skeletal muscle disorders research[1].
TCL053-based LNP induces stable genomic exon skipping and restore dystrophin protein in a DMD mouse model that harbors a humanized exon sequence[1]. | [References]
[1] Kenjo E, et al. Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in mice. Nat Commun. 2021 Dec 8;12(1):7101.
[2] Cationic lipid. JPWO2019131839A1. |
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| Company Name: |
DC Chemicals
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| Tel: |
021-58447131 13564518121 |
| Website: |
www.chemicalbook.com/showsupplierproductslist927327/0_en.htm |
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