| Identification | Back Directory | [Name]
PI3K/HDAC-IN-1 | [CAS]
2361418-52-0 | [Synonyms]
PI3K/HDAC-IN-1
PI-3K/HDAC-IN-1,PI3K/HDAC IN 1,PI3K/HDACIN1 | [Molecular Formula]
C22H25FN4O4 | [MDL Number]
MFCD32067963 | [MOL File]
2361418-52-0.mol | [Molecular Weight]
428.46 |
| Hazard Information | Back Directory | [Description]
PI3K/HDAC-IN-1 is a potent dual inhibitor of PI3K/HDAC, potently inhibits PI3Kδ and HDAC1 with IC50s of 8.1 nM and 1.4 nM, respectively[1].
PI3Kα|42 nM (IC50)|PI3Kβ|101 nM (IC50)|PI3Kγ|67 nM (IC50)|PI3Kδ|8.1 nM (IC50)|HDAC1|1.4 nM (IC50)|HDAC2|3.0 nM (IC50)|HDAC6|6.6 nM (IC50)|HDAC8|18 nM (IC50)
| [Uses]
PI3K/HDAC-IN-1 is a potent dual inhibitor of PI3K/HDAC, potently inhibits PI3Kδ and HDAC1 with IC50s of 8.1 nM and 1.4 nM, respectively[1]. | [IC 50]
PI3Kα: 42 nM (IC50); PI3Kβ: 101 nM (IC50); PI3Kγ: 67 nM (IC50); PI3Kδ: 8.1 nM (IC50); HDAC1: 1.4 nM (IC50); HDAC2: 3.0 nM (IC50); HDAC6: 6.6 nM (IC50); HDAC8: 18 nM (IC50) | [storage]
Store at -20°C | [References]
[1]. Zhang K, et al. Design, Synthesis, and Biological Evaluation of 4-Methyl Quinazoline Derivatives as Anticancer Agents Simultaneously Targeting Phosphoinositide 3-Kinases and Histone Deacetylases. J Med Chem. 2019 May 29. |
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