| Identification | Back Directory | [Name]
tert-butyl 4-(aminomethyl)-4-methylpiperidine-1-carboxylate | [CAS]
236406-22-7 | [Synonyms]
236406-22-7
4-AMinoMethyl-1-Boc-4-Met...
4-aMinoMethyl-1-t-butoxycarbony
4-AMinoMethyl-1-Boc-4-Methylpiperidine
1-Boc-4-(aMinoMethyl)-4-Methylpiperidine
1-Boc-4-methyl-4-(aminomethyl)-piperidine
4-aMinoMethyl-1-t-butoxycarbonyl-4-Methylpiperidine
tert-butyl 4-(aminomethyl)-4-methylpiperidine-1-carboxylate
1-Piperidinecarboxylic acid, 4-(aminomethyl)-4-methyl-, 1,1-dimethylethyl ester | [Molecular Formula]
C12H24N2O2 | [MDL Number]
MFCD12408568 | [MOL File]
236406-22-7.mol | [Molecular Weight]
228.334 |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of tert-butyl 4-(aminomethyl)-4-methylpiperidine-1-carboxylate from tert-butyl 4-cyano-4-methylpiperidine-1-carboxylate: Compound 25 (1.00 g, 4.46 mmol) was reacted with Rh/Al2O3 catalyst (300 mg, 5 wt%, 0.14 mmol) in a methanol-ammonia solution under hydrogen atmosphere (40 psi) ( 15 mL, 3.5 N NH3 in MeOH) was subjected to a shaking reaction. After completion of the reaction, the reaction mixture was filtered through a silica gel pad and the filtrate was concentrated to give the target product compound 26 (1.00 g, 98% yield). | [References]
[1] Patent: US2004/10013, 2004, A1. Location in patent: Page/Page column 51
[2] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 2, p. 608 - 611
[3] Patent: WO2016/77375, 2016, A1. Location in patent: Page/Page column 151 |
|
| Company Name: |
SynAsst Chemical.
|
| Tel: |
021-60343070 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15848/0_EN.htm |
| Company Name: |
NovoChemy Ltd.
|
| Tel: |
86-(0)21-31261262 373522135 |
| Website: |
www.novochemy.com |
|