| Identification | Back Directory | [Name]
7-Quinolinecarbonitrile, 1-[2-[4-[[(3,4-dihydro-3-oxo-2H-1,4-benzothiazin-6-yl)methyl]amino]-1-piperidinyl]ethyl]-1,2-dihydro-2-oxo- | [CAS]
2364479-10-5 | [Synonyms]
Antibacterial agent 236
7-Quinolinecarbonitrile, 1-[2-[4-[[(3,4-dihydro-3-oxo-2H-1,4-benzothiazin-6-yl)methyl]amino]-1-piperidinyl]ethyl]-1,2-dihydro-2-oxo- | [Molecular Formula]
C26H27N5O2S | [MOL File]
2364479-10-5.mol | [Molecular Weight]
473.59 |
| Hazard Information | Back Directory | [Uses]
Antibacterial agent 236 (Compound 4l) is an orally active inhibitor for DNA gyrase and topoisomerase IV (IC50 is 3.2 and 300 nM in Staphylococcus aureus), and exhibits board-spectrum antibacterial activity. Antibacterial agent 236 exhibits good pharmacokinetic properties in mice[1]. | [References]
[1] Desai J, et al., Discovery of aminopiperidine based potent & novel topoisomerase inhibitor with broad spectrum anti-bacterial activity. Bioorg Med Chem Lett. 2024 Oct 1;111:129911. DOI:10.1016/j.bmcl.2024.129911 |
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