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2365497-07-8

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2365497-07-8 Structure

2365497-07-8 Structure
IdentificationBack Directory
[Name]

ALK/ROS1-IN-1
[CAS]

2365497-07-8
[Synonyms]

ALK/ROS1-IN-1
ALK/ROS-1-IN-1,ALK/ROS1 IN 1,ALK/ROS1IN1
3-Piperidinecarboxamide, 1-[2-[[2-methoxy-4-(1-piperazinyl)phenyl]amino]-4-pyridinyl]-N-[[4-(trifluoromethoxy)phenyl]methyl]-, (3S)-
[Molecular Formula]

C30H35F3N6O3
[MDL Number]

MFCD34469937
[MOL File]

2365497-07-8.mol
[Molecular Weight]

584.63
Chemical PropertiesBack Directory
[Boiling point ]

767.0±60.0 °C(Predicted)
[density ]

1.286±0.06 g/cm3(Predicted)
[pka]

14.71±0.20(Predicted)
Hazard InformationBack Directory
[Uses]

ALK/ROS1-IN-1 (compound 2e) is a potent and selective anti crizotinib-resistant ALK/ROS1 dual inhibitor, with IC50s of 0.174 μM and 0.530 μM for ALK and ROS1 enzyme, respectively.
[References]

[1] Liu S, et al. Design, synthesis and biological evaluations of 2-amino-4-(1-piperidine) pyridine derivatives as novel anti crizotinib-resistant ALK/ROS1 dual inhibitors. Eur J Med Chem. 2019 Oct 1;179:358-375. DOI:10.1016/j.ejmech.2019.06.043
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