| Identification | Back Directory | [Name]
PRMT5-IN-1 | [CAS]
2366149-83-7 | [Synonyms]
PRMT5-IN-1
PRMT-5-IN-1,PRMT5 IN 1,PRMT5IN1
3H-Imidazo[1,2-c]pyrrolo[3,2-e]pyrimidin-3-ol, 7-[(5R)-5-C-(4-chlorophenyl)-β-D-ribofuranosyl]-2,7-dihydro- | [Molecular Formula]
C19H19ClN4O5 | [MDL Number]
MFCD32197238 | [MOL File]
2366149-83-7.mol | [Molecular Weight]
418.83 |
| Chemical Properties | Back Directory | [Boiling point ]
752.9±70.0 °C(Predicted) | [density ]
1.80±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
12.28±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
PRMT5 IN-1, a hemiaminal, is a potent, selective protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 11 nM for PRMT5/MEP50. PRMT5 IN-1 can be converted to aldehydes and react with C449 to form covalent adducts under physiological conditions[1]. | [IC 50]
PRMT5 | [storage]
Store at -20°C | [References]
[1] Lin H, et, al. Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors. ACS Med Chem Lett. 2019 May 22;10(7):1033-1038. DOI:10.1021/acsmedchemlett.9b00074 |
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