| Identification | Back Directory | [Name]
CDK4/6-IN-3 | [CAS]
2366237-37-6 | [Synonyms]
CDK4/6-IN-3
CDK4/6 IN 3,CDK-4/6-IN-3,CDK4/6IN3
2-Pyrimidinamine, N-[5-(6-ethyl-2,6-diazaspiro[3.3]hept-2-yl)-2-pyridinyl]-5-fluoro-4-[(4R)-5,6,7,8-tetrahydro-4-methyl-4H-pyrazolo[1,5-a]azepin-3-yl]- | [Molecular Formula]
C25H31FN8 | [MDL Number]
MFCD32197226 | [MOL File]
2366237-37-6.mol | [Molecular Weight]
462.57 |
| Chemical Properties | Back Directory | [Boiling point ]
681.1±65.0 °C(Predicted) | [density ]
1.41±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
9.13±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor with Kis of <0.3 nM and 2.2 nM, respectively. CDK4/6-IN-3 inhibits CDK1 with a Ki of 110 nM. CDK4/6-IN-3 can be used for the treatment of glioblastoma[1]. | [IC 50]
CDK4: 0.3 nM (Ki); CDK6: 2.2 nM (Ki); CDK1: 110 nM (Ki) | [storage]
Store at -20°C | [References]
[1] Bronner SM, et al. Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma. Bioorg Med Chem Lett. 2019 Aug 15;29(16):2294-2301. DOI:10.1016/j.bmcl.2019.06.021 |
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