| Identification | Back Directory | [Name]
Benzamide, 4-methyl-3-[[(4-methylphenyl)sulfonyl]amino]-N-[(6-methyl-3-pyridinyl)methyl]- | [CAS]
2366260-33-3 | [Synonyms]
Tubulin inhibitor 11
Benzamide, 4-methyl-3-[[(4-methylphenyl)sulfonyl]amino]-N-[(6-methyl-3-pyridinyl)methyl]- | [Molecular Formula]
C22H23N3O3S | [MOL File]
2366260-33-3.mol | [Molecular Weight]
409.5 |
| Hazard Information | Back Directory | [Uses]
Tubulin inhibitor 11 is a potent and orally active tubulin inhibitor. Tubulin inhibitor 11 targets the Colchicine binding site on tubulin, inhibits tubulin polymerization, promotes mitotic blockade and apoptosis[1]. | [in vivo]
Tubulin inhibitor 11 (Compound 48; 5-10 mg/kg; p.o; once daily) shows robust in vivo antitumor efficacies[1]. | Animal Model: | Male athymic BALB/c nude mice (18-20 g) injected with DU145, NCI-H1299 or A549R cells[1] | | Dosage: | 5 mg/kg, 10 mg/kg | | Administration: | p.o; once daily | | Result: | Effectively suppressed tumor growth. |
| [References]
[1] Songwen Lin, et al. Optimization of Benzamide Derivatives as Potent and Orally Active Tubulin Inhibitors Targeting the Colchicine Binding Site. J Med Chem. 2022 Dec 22;65(24):16372-16391. DOI:10.1021/acs.jmedchem.2c01208 |
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