| Identification | Back Directory | [Name]
2-Pyridinecarboxamide, 4-(5-azaspiro[2.4]hept-5-ylmethyl)-6-cyclopropyl-N-[3-[3-[(4-methyl-4H-1,2,4-triazol-3-yl)methyl]-3-oxetanyl]phenyl]- | [CAS]
2368841-84-1 | [Synonyms]
Cbl-b-IN-1
Cbl b IN 1,CblbIN1
2-Pyridinecarboxamide, 4-(5-azaspiro[2.4]hept-5-ylmethyl)-6-cyclopropyl-N-[3-[3-[(4-methyl-4H-1,2,4-triazol-3-yl)methyl]-3-oxetanyl]phenyl]- | [Molecular Formula]
C29H34N6O2 | [MDL Number]
MFCD34179488 | [MOL File]
2368841-84-1.mol | [Molecular Weight]
498.62 |
| Chemical Properties | Back Directory | [density ]
1.41±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 60 mg/mL (120.33 mM; ultrasonic and warming and heat to 60°C) | [form ]
Solid | [pka]
11.86±0.70(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
Cbl-b-IN-1 (Example 519) is an inhibitor of Cbl-b, with an IC50 of less than 100 nM. Cbl-b-IN-1 can promote the secretion of cytokines such as IL-2, IFN-γ, and TNF-α, facilitate T cell activation, and enhance the TCR signaling pathway. Cbl-b-IN-1 can be used in research on immunomodulation[1][2]. | [References]
[1] BARSANTI PAUL A (US), et al. INHIBITORS OF CBL-B AND METHODS OF USE THEREOF. WO/2019/148005A1.
[2] Wang J, et al. Cbl-b inhibition promotes less differentiated phenotypes of T cells with enhanced cytokine production. Cell Immunol. 2024 Sep-Oct;403-404:104863. DOI:10.1016/j.cellimm.2024.104863 |
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