| Identification | Back Directory | [Name]
Galegine xHCl | [CAS]
2368870-39-5 | [Synonyms]
Galegine xHCl
Galegine hydrochloride
1-(3-Methylbut-2-en-1-yl)guanidine hydrochloride | [Molecular Formula]
C6H14ClN3 | [MDL Number]
MFCD32069582 | [MOL File]
2368870-39-5.mol | [Molecular Weight]
163.65 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
|DMSO : 5.2 mg/mL (31.78 mM) | [form ]
Solid | [color ]
White to off-white | [Water Solubility ]
Water : 43.33 mg/mL (264.77 mM) |
| Hazard Information | Back Directory | [Uses]
Galegine hydrochloride, a guanidine derivative, contributes to weight loss in mice. Guanidine hydrochloride is the compound derived from G. officinalis, which gave rise to the biguanides, metformin and phenformin. Galegine hydrochloride activates AMPK in 3T3-L1 adipocytes and L6 myotubes, as well as in the H4IIE rat hepatoma and HEK293 human kidney cell lines. Galegine hydrochloride has antibacterial activity, with minimum inhibitory concentration of 4 mg/L against Staphylococcus aureus strains[1][2]. | [in vivo]
Galegine hydrochloride (63 mg/kg; feed; daily for 11 days) produces a significant reduction in body weight[1]. | Animal Model: | Adult male BALB/c mice[1] | | Dosage: | 63 mg/kg | | Administration: | feed; daily for 11 days | | Result: | Produced a significant reduction in body weight. |
| [References]
[1] Mooney MH, et al. Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice. Br J Pharmacol. 2008 Apr;153(8):1669-77. DOI:10.1038/bjp.2008.37
[2] Coqueiro A, et al. In Vitro Antibacterial Activity of Prenylated Guanidine Alkaloids from Pterogyne nitens and Synthetic Analogues. J Nat Prod. 2014 Aug 22;77(8):1972-5. DOI:10.1021/np500281c |
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