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2368900-33-6

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2368900-33-6 Structure

2368900-33-6 Structure
IdentificationBack Directory
[Name]

CMLD012072
[CAS]

2368900-33-6
[Synonyms]

CMLD012072
3H-Benzofuro[3',2':1,5]cyclopent[1,2-d]imidazole-4-carboxylic acid, 2-cyclopropyl-3a,4,5,5a-tetrahydro-3a-hydroxy-8,10-dimethoxy-5a-(4-methoxyphenyl)-5-phenyl-, methyl ester, (3aR,4R,5S,5aR,10bR)-
[Molecular Formula]

C32H32N2O7
[MDL Number]

MFCD34469622
[MOL File]

2368900-33-6.mol
[Molecular Weight]

556.61
Chemical PropertiesBack Directory
[Boiling point ]

726.2±60.0 °C(Predicted)
[density ]

1.40±0.1 g/cm3(Predicted)
[pka]

12.31±0.70(Predicted)
Hazard InformationBack Directory
[Uses]

CMLD012072 is an amidino-rocaglates and is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. CMLD012072 can induce RNA clamping of eIF4A1 and eIF4A2 and possess potent anti-neoplastic activity[1].
[References]

[1] Chu J, et al. Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors. Cell Chem Biol. 2019 Nov 21;26(11):1586-1593. DOI:10.1016/j.chembiol.2019.08.008
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