| Identification | Back Directory | [Name]
KDM4-IN-2 | [CAS]
2369607-62-3 | [Synonyms]
KDM4-IN-2
KDM4 IN 2,KDM-4-IN-2,KDM4IN2
Pyrido[3,4-d]pyrimidin-4(3H)-one, 8-[4-[2-(2,3-dihydrospiro[1H-indene-1,4'-piperidin]-1'-yl)ethyl]-1H-pyrazol-1-yl]- | [Molecular Formula]
C25H26N6O | [MDL Number]
MFCD32174289 | [MOL File]
2369607-62-3.mol | [Molecular Weight]
426.51 |
| Chemical Properties | Back Directory | [Boiling point ]
635.8±65.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
9.43±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
KDM4-IN-2 (Compound 19a) is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7?nM for KDM4A and KDM5B, respectively[1]. | [IC 50]
KDM4 | [storage]
Store at -20°C | [References]
[1] Le Bihan YV, et al. C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays. Eur J Med Chem. 2019 Sep 1;177:316-337. DOI:10.1016/j.ejmech.2019.05.041 |
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