| Identification | Back Directory | [Name]
2-Propenamide, N-[5-[[4-[[5-chloro-4-fluoro-2-(1-hydroxy-1-methylethyl)phenyl]amino]-2-pyrimidinyl]amino]-2-[(3S)-3-(dimethylamino)-1-pyrrolidinyl]-4-methoxyphenyl]- | [CAS]
2370013-49-1 | [Synonyms]
DZD9008
2-Propenamide, N-[5-[[4-[[5-chloro-4-fluoro-2-(1-hydroxy-1-methylethyl)phenyl]amino]-2-pyrimidinyl]amino]-2-[(3S)-3-(dimethylamino)-1-pyrrolidinyl]-4-methoxyphenyl]- | [Molecular Formula]
C29H35ClFN7O3 | [MDL Number]
MFCD34603702 | [MOL File]
2370013-49-1.mol | [Molecular Weight]
584.08 |
| Chemical Properties | Back Directory | [density ]
1.35±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 50 mg/mL (85.60 mM; Need ultrasonic) | [form ]
Solid | [pka]
12.29±0.70(Predicted) | [color ]
White to off-white | [InChIKey]
BTMKEDDEMKKSEF-KRWDZBQOSA-N | [SMILES]
C(NC1=CC(NC2=NC=CC(NC3=CC(Cl)=C(F)C=C3C(O)(C)C)=N2)=C(OC)C=C1N1CC[C@H](N(C)C)C1)(=O)C=C |
| Hazard Information | Back Directory | [Uses]
(S)-Sunvozertinib ((S)-DZD9008), the S-enantiomer of Sunvozertinib, shows inhibitory activity against EGFR exon 20 NPH and ASV insertions, EGFR L858R/T790M mutation and Her2 exon20 YVMA insertion (IC50=51.2 nM, 51.9 nM, 1 nM, and 21.2 nM, respectively). (S)-Sunvozertinib also inhibits BTK[1]. | [Biological Activity]
(S)-Sunvozertinib ((S)-DZD9008), the S-enantiomer of Sunvozertinib, shows inhibitory activity against EGFR exon 20 NPH and ASV insertions, EGFR L858R/T790M mutation and Her2 exon20 YVMA insertion (IC50=51.2 nM, 51.9 nM, 1 nM, and 21.2 nM, respectively). (S)-Sunvozertinib also inhibits BTK[1].
(S)-Sunvozertinib shows proliferation inhibition of Ba/F3 EGFR NPH ins (GI50=139.7 nM), Ba/F3 FGFR ASV ins (155.7 nM), NCI-HI975 EGFRL858R/T790M (24.4), Her2 YVMA ins (827 nM) and WT EGFR (84.8 nM)[1].(S)-Sunvozertinib shows proliferation inhibition of BTK WT cells (OCI-LY-10, TMD-8, Ri-1and DB, with GI50 ranging from 13.7-48 nM)[1]. | [IC 50]
EGFR exon 20 NPH: 51.2 nM (IC50); EGFR exon 20 ASV insertion: 51.9 nM (IC50); EGFRL858R/T790M: 1 nM (IC50); Her2 exon 20 YVMA insertion: 21.2 nM (IC50) | [References]
[1]. Zhengtao LI, et al. Erbb/btk inhibitors. WO2019149164A1. |
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BOC Sciences
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1-631-485-4226; 16314854226 |
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https://www.bocsci.com |
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